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Article Dans Une Revue Brain Research Année : 1997

Effect of an NMDA receptor antagonist on the wind-up of neurons in the trigeminal oralis subnucleus

C.A. Parada
  • Fonction : Auteur
P. Luccarini
  • Fonction : Auteur
A. Woda
  • Fonction : Auteur

Résumé

Extracellular recordings of convergent neurons of the oralis subnucleus of the trigeminal sensory complex were performed in paralysed rats under halothane-N O-O anesthesia using glass micropipettes. The effects of MK801, a noncompetitive NMDA receptor 2 2 Ž. Ž. antagonist, were observed on the increased cell activity wind-up , triggered by the repetition, at a low frequency 0.66 Hz and high Ž. Ž intensity 3 times the threshold of C-fiber response , of electrical stimulation of the receptive field. Successive cumulative doses up to 1. Ž. mgrkg of MK801 i.v. resulted in a dose-dependent decrease in the responses related to C-fiber input 11 cells. A single dose of 1 mgrkg applied in four cells had effects similar to the 1 mgrkg dose given cumulatively. Three units were either weakly or not modified Ž by MK801. In a second experiment, recordings were performed in 12 cells for 80 min after an injection of a small dose of MK801 0.15. mgrkg. C input was not significantly modified by the antagonist. The effects of MK801 on the first part of the wind-up response Ž. wind-up proper peaked between 15 and 50 min and returned to control values at about 80 min. The effects on the postdischarge followed approximately the same time course. It is concluded that despite being devoid of substantia gelatinosa, the oralis subnucleus contains neurons that display an NMDA receptor-linked wind-up similar to the phenomenon described in the dorsal horn of the spinal cord. q 1997 Elsevier Science B.V.

Dates et versions

hal-04342380 , version 1 (13-12-2023)

Identifiants

Citer

C.A. Parada, P. Luccarini, A. Woda. Effect of an NMDA receptor antagonist on the wind-up of neurons in the trigeminal oralis subnucleus. Brain Research, 1997, 761 (2), pp.313-320. ⟨10.1016/s0006-8993(97)00355-7⟩. ⟨hal-04342380⟩

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