Article Dans Une Revue Journal of Alzheimer's Disease Année : 2020

Modelling Awareness in Alzheimer’s Disease

Résumé

Abstract. This study aimed to provide a model of awareness in Alzheimer’s disease using the stage of the disease as a risk factor. Awareness was assessed using three methods (patient-caregiver discrepancy, prediction-performance discrepancy, clinical rating). Twenty-five healthy control subjects and sixty-one patients participated, with measures of cognition, apathy, depression, and awareness. These measures were introduced into a manual backward regression. Confounding factors impacting at least 15% of the exposure factor estimate were maintained in the model. Except for the prediction performance discrepancy, also presenting cognitive associations, the other awareness assessments suggested a major role of depression and apathy as impacting factors.

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hal-04336270 , version 1 (11-12-2023)

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Jean-Pierre Jacus, Amandine Mayelle, Virginie Voltzenlogel, Christine-Vanessa Cuervo-Lombard, Pascal Antoine. Modelling Awareness in Alzheimer’s Disease. Journal of Alzheimer's Disease, 2020, 76 (1), pp.89-95. ⟨10.3233/JAD-200017⟩. ⟨hal-04336270⟩
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