Amivantamab Compared with Real-World Physician’s Choice after Platinum-Based Therapy from a Pan-European Chart Review of Patients with Lung Cancer and Activating EGFR Exon 20 Insertion Mutations - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2023

Amivantamab Compared with Real-World Physician’s Choice after Platinum-Based Therapy from a Pan-European Chart Review of Patients with Lung Cancer and Activating EGFR Exon 20 Insertion Mutations

Petros D. Christopoulos
Claudia Proto
Marta S. Soares
  • Fonction : Auteur
Pilar Garrido Lopez
  • Fonction : Auteur
Anthonie J. van der Wekken
Sanjay Popat
Joris Diels
  • Fonction : Auteur
Claudio A. Schioppa
Jan Sermon
  • Fonction : Auteur
Nora Rahhali
  • Fonction : Auteur
Corinna Pick-Lauer
  • Fonction : Auteur
Agnieszka Adamczyk
  • Fonction : Auteur
James Penton
  • Fonction : Auteur
Marie Wislez

Résumé

Patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor gene (EGFR) Exon 20 insertions (Exon20ins) at the second line and beyond (2L+) have an unmet need for new treatment. Amivantamab, a bispecific EGFR- and MET-targeted antibody, demonstrated efficacy in this setting in the phase 1b, open-label CHRYSALIS trial (NCT02609776). The primary objective was to compare the efficacy of amivantamab to the choices made by real-world physicians (RWPC) using an external control cohort from the real-world evidence (RWE) chart review study, CATERPILLAR-RWE. Adjustment was conducted to address differences in prognostic variables between cohorts using inverse probability weighting (IPW) and covariate adjustments based on multivariable regression. In total, 114 patients from CHRYSALIS were compared for 55 lines of therapy from CATERPILLAR-RWE. Baseline characteristics were comparable between the amivantamab and IPW-weighted RWPC cohorts. For amivantamab versus RWPC using IPW adjustment, the response rate ratio for the overall response was 2.14 (p = 0.0181), and the progression-free survival (PFS), time-to-next-treatment (TTNT) and overall survival (OS) hazard ratios (HRs) were 0.42 (p < 0.0001), 0.47 (p = 0.0063) and 0.48 (p = 0.0207), respectively. These analyses provide evidence of clinical and statistical benefits across multiple outcomes and adjustment methods, of amivantamab in platinum pre-treated patients with advanced NSCLC harboring EGFR Exon20ins. These results confirm earlier comparisons versus pooled national registry data.
Fichier principal
Vignette du fichier
cancers-15-05326-v2.pdf (5.51 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04334506 , version 1 (22-12-2023)

Licence

Identifiants

Citer

Petros D. Christopoulos, Nicolas Girard, Claudia Proto, Marta S. Soares, Pilar Garrido Lopez, et al.. Amivantamab Compared with Real-World Physician’s Choice after Platinum-Based Therapy from a Pan-European Chart Review of Patients with Lung Cancer and Activating EGFR Exon 20 Insertion Mutations. Cancers, 2023, 15 (22), ⟨10.3390/cancers15225326⟩. ⟨hal-04334506⟩
29 Consultations
6 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More