Article Dans Une Revue Science Advances Année : 2023

Genetically determined thymic function affects strength and duration of immune response in COVID patients with pneumonia

Hélène Roux
Amira Marouf
Jacques Dutrieux
Suzanne Figueiredo-Morgado
  • Fonction : Auteur
Véronique Avettand-Fenoel
Pelagia Cuvelier
Cécile Naudin
  • Fonction : Auteur
Fatma Bouaziz
  • Fonction : Auteur
Guillaume Geri
  • Fonction : Auteur
Anne Couëdel-Courteille
Pierre Squara
  • Fonction : Auteur
Rémi Cheynier

Résumé

Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The rs2204985 genetic polymorphism within the TCRA-TCRD locus, which affects thymic output in healthy individuals, was found here to modify SARS-CoV-2–specific immunity and disease severity in COVID-19 patients with severe pneumonia. Forty patients with severe COVID-19 pneumonia were investigated. The GG genotype at the rs2204985 locus was associated, independently of age and sex, with stronger and long-lasting anti–SARS-CoV-2 helper and cytotoxic T cell responses 6 months after recovery. The GG genotype was also associated with less severe lung involvement, higher thymic production, and higher counts of blood naïve T lymphocytes, including recent thymic emigrants, and a larger population of activated stem cell memory CD4 + T cells. Overall, GG patients developed a more robust and sustained immunity to SARS-CoV-2. Polymorphism at rs2204985 locus should be considered as an additional predictive marker of anti–SARS-CoV-2 immune response.

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hal-04331411 , version 1 (08-12-2023)

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Hélène Roux, Amira Marouf, Jacques Dutrieux, Bénédicte Charmeteau-de Muylder, Suzanne Figueiredo-Morgado, et al.. Genetically determined thymic function affects strength and duration of immune response in COVID patients with pneumonia. Science Advances , 2023, 9 (38), ⟨10.1126/sciadv.adh7969⟩. ⟨hal-04331411⟩

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