Using a dynamical model to study the impact of a toxoid vaccine on the evolution of a bacterium: The example of diphtheria - Archive ouverte HAL Access content directly
Journal Articles Ecological Modelling Year : 2024

Using a dynamical model to study the impact of a toxoid vaccine on the evolution of a bacterium: The example of diphtheria

Abstract

Vaccines are one of humankind's greatest weapons against infectious diseases. However, their usefulness is often questioned and the public tends to distrust vaccines. A mathematical model published in the early 2000s predicts the selection of more virulent strains of pathogens when populations are protected with imperfect vaccines, i.e., vaccines which reduce but do not entirely block pathogen transmission, such as toxoid vaccines. In this study, we built a disease-specific competition model to analyze the evolution of diphtheria's virulence under the pressure of a toxoid vaccine. Our results show that i) high vaccine coverage favors the emergence and increase prevalence of avirulent (or less virulent) strains of Corynebacterium diphtheriae (the etiologic agent of diphtheria) and ii) that competition between strains is crucial in the eradication of toxigenic strains when toxoid vaccines are used. We conclude that the use of toxoid vaccines could lead to disease eradication if the interaction between strains is taken into account. Our results could extend to biologically similar systems such as pertussis.
Fichier principal
Vignette du fichier
1-s2.0-S0304380023002995-main.pdf (1.56 Mo) Télécharger le fichier
Origin Publication funded by an institution
Licence

Dates and versions

hal-04330503 , version 1 (08-12-2023)

Licence

Identifiers

Cite

Florian Lecorvaisier, Dominique Pontier, Benoît Soubeyrand, David Fouchet. Using a dynamical model to study the impact of a toxoid vaccine on the evolution of a bacterium: The example of diphtheria. Ecological Modelling, 2024, 487, pp.110569. ⟨10.1016/j.ecolmodel.2023.110569⟩. ⟨hal-04330503⟩
54 View
25 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More