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Article Dans Une Revue Trends in Microbiology Année : 2021

Conserved DNA Methyltransferases: A Window into Fundamental Mechanisms of Epigenetic Regulation in Bacteria

Résumé

An increasing number of studies have reported that bacterial DNA methylation has important functions beyond their roles in restriction-modification systems, including the ability of affecting clinically relevant phenotypes such as virulence, host colonization, sporulation, biofilm formation, among others. Although insightful, such studies have a largely ad hoc nature, and would benefit from a systematic strategy enabling a joint functional characterization of bacterial methylomes by the Microbiology community. In this Opinion, we propose that highly conserved DNA methyltransferases (MTases) represent a unique opportunity for bacterial epigenomic studies. These MTases are rather common in Bacteria, span various taxonomic scales, and are present in multiple human pathogens. Apart from well characterized core DNA MTases, like those from Vibrio cholera, Salmonella enterica, Clostridioides difficile or Streptococcus pyogenes, multiple highly conserved DNA MTases are also found in numerous human pathogens including those belonging to the genera Burkholderia and Acinetobacter. We discuss why and how these MTases can be prioritized to enable a community-wide, integrative approach for functional epigenomic studies. Ultimately, we discuss how some highly conserved DNA MTases may emerge as promising targets for the development of novel epigenetic inhibitors for biomedical applications.
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hal-04325259 , version 1 (05-12-2023)

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Pedro H. Oliveira, Gang Fang. Conserved DNA Methyltransferases: A Window into Fundamental Mechanisms of Epigenetic Regulation in Bacteria. Trends in Microbiology, 2021, 29 (1), pp.28-40. ⟨10.1016/j.tim.2020.04.007⟩. ⟨hal-04325259⟩
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