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Article Dans Une Revue ACTA ENDOCRINOLOGICA Année : 1992

Iodide and T4 kinetics in plasma, thyroid gland and skin of 10-day-old rats: effects of iodine deficiency

François Gondran
  • Fonction : Auteur
Mebarka Redjem
  • Fonction : Auteur
Marie-Dominique Giudicelli
  • Fonction : Auteur
Youssef Aissouni
Emile Vigouroux
  • Fonction : Auteur

Résumé

The effects of iodine deficiency on the peripheral metabolism of thyroid hormone in immature rat were evaluated by measuring the kinetics of iodide and thyroxine (T 4 ) in control and iodine-deficient 10-day-old rats. Iodine-deficient pups were obtained by giving the mother drinking water containing perchlorate; this anion is not transferred but prevents iodine transfer in the mother's milk. Labelled iodocompounds were measured in plasma, thyroid and skin for 48 h following intravenous injection of Na 131 I plus [ 125 I]T 4 . Data were interpreted by compartmental analysis. The iodide plasma clearance rate, plasma equivalent distribution volume, plasma concentration, production and iodine thyroid content of iodine-deficient rats were significantly lower (−29%, −31%, −84%, −89% and −87% respectively) than in control 10-day-old rats. The iodide thyroid uptake was reduced (−47%) but remained higher than the release of iodine as T 4 . Cutaneous iodine was lost much more quickly by iodine-deficient pups than by control pups, explaining the decreased iodide distribution volume. The parameters of T 4 metabolism were not changed by iodine deficiency, except for a slight but significant reduction of the thyroxinemia and T 4 pools (−13%). Thence, T 4 production was not significantly changed (about 8 pmol/h in control and iodine-deficient rats). The labelled T 4 curves in iodine-deficient and control skin were superimposed and the patterns of labelled T 3 derived from [ 125 I]T 4 were identical. Thus, the skin of immature rats converts T 4 to T 3 ; this process was not disturbed by iodine deficiency. The thyroid function of immature rats is particularly resistant to iodine deficiency, but the mechanisms remain unknown.
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Dates et versions

hal-04323805 , version 1 (05-12-2023)

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Citer

Najiba Zeghal, François Gondran, Mebarka Redjem, Marie-Dominique Giudicelli, Youssef Aissouni, et al.. Iodide and T4 kinetics in plasma, thyroid gland and skin of 10-day-old rats: effects of iodine deficiency. ACTA ENDOCRINOLOGICA, 1992, 127 (5), pp.425-434. ⟨10.1530/acta.0.1270425⟩. ⟨hal-04323805⟩

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