The p-center problem consists of choosing p centers from a set of candidates to minimize the maximum distance between any client and its assigned center. In this paper, we transform the p-center problem into a series of set covering subproblems, and propose a vertex weighting-based tabu search (VWTS) algorithm to solve them. The proposed VWTS algorithm integrates distinguishing features such as a vertex weighting technique and a tabu search strategy to help the search to jump out of the local optima. Computational experiments on 138 most commonly used benchmark instances show that VWTS is highly competitive comparing to the state-of-the-art methods in spite of its simplicity. As a well-known NP-hard problem which has already been studied for over half a century, it is a challenging task to break the records on these classic datasets. Yet VWTS improves the best known results for 14 out of 54 large instances, and matches the optimal results for all remaining 84 ones. In addition, the computational time taken by VWTS is much shorter than other algorithms in the literature.