Statistical Analysis of Ceiling and Floor Effects in Medical Trials - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Applied Biosciences Année : 2023

Statistical Analysis of Ceiling and Floor Effects in Medical Trials

Résumé

Exploratory data analysis and statistical moments were used to investigate the potential impact of ceiling and floor effects in medical trials. A total of 150 treatment-naive eyes were assessed in a retrospective case study of patients who were treated with anti-VEGF injections for wet age-related macular degeneration. The experimental results revealed that ceiling and floor effects are problematic in data analysis and may result in serious errors when using standard parametric tests. The case study provided insights relating to methodology in medical trials, experimental data analysis, and statistical inference, as applied to the interpretation of treatment response limits. Suggestions are provided for statistical data pre-processing and post-processing when significantly skewed distributions are present in response groups.
Fichier principal
Vignette du fichier
applbiosci-02-00042-v2.pdf (2.46 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04320932 , version 1 (04-12-2023)
hal-04320932 , version 2 (05-12-2023)

Identifiants

Citer

Janan Arslan, Kurt Benke. Statistical Analysis of Ceiling and Floor Effects in Medical Trials. Applied Biosciences, 2023, ⟨10.3390/applbiosci2040042⟩. ⟨hal-04320932v2⟩
13 Consultations
7 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More