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Communication Dans Un Congrès Année : 2023

Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism

Résumé

Alcohol-dependent patients commonly show impairments in executive functions that facilitate craving and can lead to relapse. However, the molecular mechanisms leading to executive dysfunction in alcoholism are poorly understood, and new effective pharmacological treatments are desired. Here, using a bidirectional neuromodulation approach, we demonstrate a causal link between reduced prefrontal mGluR2 function and both impaired executive control and alcohol craving. A neuron-spe- cific prefrontal mGluR2 knockdown in rats generated a phenotype of reduced cognitive flexibility and excessive alcohol seeking. Conversely, virally restoring prefrontal mGluR2 levels in alcohol-dependent rats rescued these pathological behaviors. In the search for a pharmacological intervention with high translational potential, psilocybin was capable of restoring mGluR2 expression and reducing relapse behavior. Last, we propose an FDG-PET biomarker strategy to identify mGluR2 treatment- responsive individuals. In conclusion, we identified a common molecular pathological mechanism for both executive dysfunction and alcohol craving and provided a personalized mGluR2 mechanism-based inter- vention strategy for medication development for alcoholism.
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Dates et versions

hal-04319758 , version 1 (03-12-2023)

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Marcus Meinhardt, Grégory Fouquet, Jérôme Jeanblanc, Anita Hansson, Richard Bell, et al.. Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism. Alcoholism and Stress: A Framework For Future Treatment Strategies, Dr Marisa Roberto, May 2023, Volterra, Tuscany, Italy. pp.91, ⟨10.1016/j.alcohol.2023.03.099⟩. ⟨hal-04319758⟩

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