Demonstration of a new-to-nature pathway for ATP-driven reduction of CO2 to formate in vivo
Résumé
• Direct CO2-reduction to formate is found in natural
metabolic routes such as the Wood-Ljungdahl pathway. The
reaction is catalyzed by formate dehydrogenases (FDH),
which transfer 2e– from H2, ferredoxins or NADPH to CO2.
• However, for organisms growing in aerobic conditions and
at ambient CO2-concentrations (400 ppm), direct CO2-
reduction has remained infeasible due to severe thermodynamic
and kinetic constraints on the FDH reaction.