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Poster De Conférence Année : 2023

Demonstration of a new-to-nature pathway for ATP-driven reduction of CO2 to formate in vivo

Matthias Heinemann

Résumé

• Direct CO2-reduction to formate is found in natural metabolic routes such as the Wood-Ljungdahl pathway. The reaction is catalyzed by formate dehydrogenases (FDH), which transfer 2e– from H2, ferredoxins or NADPH to CO2. • However, for organisms growing in aerobic conditions and at ambient CO2-concentrations (400 ppm), direct CO2- reduction has remained infeasible due to severe thermodynamic and kinetic constraints on the FDH reaction.
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Dates et versions

hal-04316289 , version 1 (30-11-2023)

Identifiants

  • HAL Id : hal-04316289 , version 1

Citer

Ari Satanowski, Daniel Marchal, Alain Perret, Jean-Louis Petit, Madeleine Bouzon, et al.. Demonstration of a new-to-nature pathway for ATP-driven reduction of CO2 to formate in vivo. Metabolic Engineering 15 conference, Jun 2023, Singapoure, Malaysia. ⟨hal-04316289⟩
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