Article Dans Une Revue Journal of Neuroscience Année : 2023

The Effects of Free Breathing on Cerebral Venous Flow: a real-time phase contrast MRI study in healthy adults

Résumé

Quantifying the effects of free breathing on cerebral venous flow is crucial for understanding cerebral circulation mechanisms and clinical applications. Unlike conventional cine phase-contrast MRI sequences (CINE-PC), real-time phase-contrast MRI sequences (RT-PC) can provide a continuous beat-to-beat flow signal that makes it possible to quantify the effect of breathing on cerebral venous flow. In this study, we examined 28 healthy human participants, comprising of 14 males and 14 females. Blood flows in the right/left internal jugular veins in the extracranial plane and the superior sagittal sinus and straight sinus in the intercranial plane were quantified using CINE-PC and RT-PC. The first objective of this study was to determine the accuracy of RT-PC in quantifying cerebral venous flow, relative to CINE-PC. The second, and main objective, was to quantify the effect of free breathing on cerebral venous flow, using a time-domain multiparameter analysis method. Our results showed that RT-PC can accurately quantify cerebral venous flow with a 2×2 mm 2 spatial resolution and 75 ms/image time resolution. The mean flow rate, amplitude, stroke volume and cardiac period of cerebral veins were significantly higher from the mid-end phase of expiration to the mid-end phase of inspiration. Breathing affected the mean flow rates in the jugular veins more than those in the superior sagittal sinus and straight sinus. Furthermore, the effects of free breathing on the flow rate of the left and right jugular veins were not synchronous. These new findings provide a useful reference for better understanding the mechanisms of cerebral circulation. Significance Statement Currently, the effects of free breathing on cerebral venous flow are not well-understood. In this study, we first validated the accuracy of real-time phase-contrast sequences in quantifying cerebral venous blood flow. Subsequently, we used a novel analytical method to confirm and quantify the effects of free breathing on various parameters of cerebral venous flow across both intracranial and extracranial planes. We found that the influence of free breathing varies between these planes, and its effects on the cardiac period and blood flow are asynchronous. These novel findings provide a new perspective for understanding cerebral circulation mechanisms, particularly cerebrospinal fluid circulation, and offer valuable insights for advancing clinical research and treatment strategies.

Dates et versions

hal-04315803 , version 1 (30-11-2023)

Identifiants

Citer

Pan Liu, Heimiri Monnier, K. P. Owashi, Jean-Marc Constans, Cyrille Capel, et al.. The Effects of Free Breathing on Cerebral Venous Flow: a real-time phase contrast MRI study in healthy adults. Journal of Neuroscience, 2023, 94, pp.JN-RM-0965-23. ⟨10.1523/JNEUROSCI.0965-23.2023⟩. ⟨hal-04315803⟩
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