Calcium carbonate theranostic agent in an ultrasound field
Résumé
Theranostic agents are materials that act both as tracers during diagnostic imaging and as vehicles carrying and releasing therapeutics during treatment. Ultrasound-triggered theranostic agents comprise shell-encapsulated microbubbles that pulsate during low-amplitude sonication and release their payload upon higher-amplitude sonication. High-amplitude sonication may be undesirable due to unwanted side effects related to inertial cavitation. However, low-amplitude release from microbubbles typically requires thin encapsulating shells, which in turn may be permanently disrupted under diagnostic imaging conditions. The purpose of this study was to investigate a novel microbubble agent with thick shells composed of calcium carbonate.
Domaines
Physique Médicale [physics.med-ph]
Origine : Fichiers produits par l'(les) auteur(s)