Growth retardation induced by protein and indispensable amino acid deficiencies cannot be catch up by a supplementation in growing rats. - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2022

Growth retardation induced by protein and indispensable amino acid deficiencies cannot be catch up by a supplementation in growing rats.

Résumé

• Background & Objectives: In developing countries, children are exposed to a growth retardations risk due to their low protein (LP) intake or poor quality of protein sources. However, the specificity of each indispensable amino acid (IAA) and the ability of children to catch-up their growth retardation remains unclear. The aim of this study was to assess the supplementation efficiency following a protein or IAA (lysine, threonine, and methionine) deficiencies in growing rats, and to identify the specific IAA deficiency effect. • Methods: Sixty growing rats were fed by a control (20% of proteins; P20), a LP (5% of proteins; LP) or IAA deficient (25% of the rat’s requirement in lysine, threonine, or methionine; L25, T25 and M25) diets for 3w. Thereafter, all rats were supplemented by the control (P20) or a control-equivalent diet containing free AA. Body weight (BW) and food intake were daily recorded. Naso-anal length (NAL), bone mineral density (BMD) and body composition were measured at the end of each period. • Results: During the deficiency, IAA as LP diets reduced BW gain from day 2 for LP, L25 and M25 and from day 1 for T25. The BW was reduced by 30% for L25 and M25, 50% for LP and 60% for T25. The NAL was also reduced by 9, 18, 25% for L25 /M25, LP and T25. At the end of the deficiency, all groups had less lean body mass (LBM), whereas only LP and T25 had a decreased BMD. During the supplementation, growth resumes and the weight’s gap between each group was reduced, but remains after supplementation. The BW were reduced by 15, 25 and 35% for L25/M25, LP and T25, respectively. For NAL and LBM, the gap slightly reduced too, but the difference remains after the supplementation. Indeed, the NAL was reduced by 5% for L25 and M25, 8% for LP and 10% for T25. All groups had reduced kidney, muscle and carcass weight, and LP and T25 had a reduced liver weight and BMD. • Conclusions: A single IAA deficiency as LP induced growth retardation, and the LBM is highly affected. A supplementation allows growth resume, but the growth retardation cannot be catch up.
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Dates et versions

hal-04314307 , version 1 (30-01-2024)

Identifiants

  • HAL Id : hal-04314307 , version 1

Citer

Gaëtan Roisné-Hamelin, Catherine C. Chaumontet, Claire C. Gaudichon, Juliane Calvez, Daniel Tomé, et al.. Growth retardation induced by protein and indispensable amino acid deficiencies cannot be catch up by a supplementation in growing rats.. International Congress of nutrition (ICN), Dec 2022, Tokyo (Japan), Japan. ⟨hal-04314307⟩
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