Poster De Conférence Année : 2008

Effect of relapse on cognition for patients with multiple sclerosis (MS).

Résumé

INTRODUCTION: The existence of cognitive variation during relapses or relapses with only cognitive signs are not well established though that could induce change for the treatments. OBJECTIVE: To describe cognitive profile during the relapse and to look for some cognitive variation after relapse. METHOD: A comprehensive french neuropsychological battery (BCcogSEP) (based on the BRB-N) was carried out during the relapse (before the corticoid administration) and 4 months after. Anxiety, depression and fatigue were assessed during and after the relapse with FIS, BDI-II and STAI. RESULTS: 18 patients were included. 7 didn’t have bcCogSEP tests after the relapse. Median’s EDSS before the relapse was 4.5. During the relapse, 55 % had cognitive impairment. 30 % had slower information processing and sustained attention deficit, 21 % had deficit in executive functions, 19 % had fewer short term and/or working memory capacities, 9 % had verbal or visual episodic memory deficit. There wasn’t correlation between cognitive performances and depression, anxiety, or fatigue. Without the influence of training into analyse, there was a significant improvement after relapse for sustained attention (PASAT 2sec.; p<0,026), immediate recall (p<0,013) and delayed recall of SRT (p<0,024). In contrast, with the training effect into analyse, by a specific coefficient of ponderation (Dujardin et al., 2004), there was a significant worsening for attention (code subtest) (p<0,016) and short term memory (direct digit span) (p<0,01) and a trend of improvement for delayed recall of SRT (p<0,55). DISCUSSION: There don’t find a specific cognitive profile during relapse. The paradoxical cognitive worsening after relapse can be explained by: - longer cognitive improvement than physical improvement, - longer duration of relapse than 4 months, - higher coefficient of ponderation, calculated for healthy subjects and not for MS patients. CONCLUSION: There is cognitive variation during relapse of MS, with a cognitive profile similar to the one during the remission

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Dates et versions

hal-04312584 , version 1 (28-11-2023)

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  • HAL Id : hal-04312584 , version 1

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Charlotte Crinquette, Bruno Lenne, Alexandre Mackowiak, Patrick Hautecoeur. Effect of relapse on cognition for patients with multiple sclerosis (MS).. Annual Meeting of Amercican Academy of Neurology (AAN), Apr 2008, Chicago, United States. Neurology, 70 (16 Supplement 1), 2008. ⟨hal-04312584⟩

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