Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in <scp>sub‐Saharan</scp> Africa (the <scp>BIOCADRE</scp> study) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue British Journal of Haematology Année : 2023

Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub‐Saharan Africa (the BIOCADRE study)

Brigitte Ranque
Oumar Tessougue
  • Fonction : Auteur
Serigne Mourtalla Gueye
  • Fonction : Auteur
Yves Colin‐aronovicz
  • Fonction : Auteur
Marc Romana
Caroline Le van Kim

Résumé

Summary Sickle cell anaemia (SCA) is a monogenic disease with a highly variable clinical course. We aimed to investigate associations between microvascular function, haemolysis markers, blood viscosity and various types of SCA‐related organ damage in a multicentric sub‐Saharan African cohort of patients with SCA. In a cross‐sectional study, we selected seven groups of adult patients with SS phenotype in Dakar and Bamako based on the following complications: leg ulcer, priapism, osteonecrosis, retinopathy, high tricuspid regurgitant jet velocity (TRV), macro‐albuminuria or none. Clinical assessment, echocardiography, peripheral arterial tonometry, laboratory tests and blood viscosity measurement were performed. We explored statistical associations between the biological parameters and the six studied complications. Among 235 patients, 58 had high TRV, 46 osteonecrosis, 43 priapism, 33 leg ulcers, 31 retinopathy and 22 macroalbuminuria, whereas 36 had none of these complications. Multiple correspondence analysis revealed no cluster of complications. Lactate dehydrogenase levels were associated with high TRV, and blood viscosity was associated with retinopathy and the absence of macroalbuminuria. Despite extensive phenotyping of patients, no specific pattern of SCA‐related complications was identified. New biomarkers are needed to predict SCA clinical expression to adapt patient management, especially in Africa, where healthcare resources are scarce.
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hal-04312389 , version 1 (28-11-2023)

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Brigitte Ranque, Mor Diaw, Abdoul Karim Dembele, Claudine Lapoumeroulie, Lucile Offredo, et al.. Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub‐Saharan Africa (the BIOCADRE study). British Journal of Haematology, 2023, 203 (2), pp.319 - 326. ⟨10.1111/bjh.19006⟩. ⟨hal-04312389⟩
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