Early castration in horses does not impact osteoarticular metabolism - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Early castration in horses does not impact osteoarticular metabolism

Résumé

The castration of stallions is traditionally performed after puberty, at around the age of 2 years old. No studies have focused on the effects of early castration on osteoarticular metabolism. Thus, we aimed to compare early castration (3 days after birth) with traditional castration (18 months of age) in horses. Testosterone and estradiol levels were monitored from birth to 33 months in both groups. We quantified the levels of biomarkers of cartilage and bone anabolism (CPII and N-MID) and catabolism (CTX-I and CTX-II), as well as of osteoarthritis (HA and COMP) and inflammation (IL-6 and PGE2). We observed a lack of parallelism between testosterone and estradiol synthesis after birth and during puberty in both groups. The extra-gonadal synthesis of steroids was observed around the 28-month mark, regardless of the castration age. We found the expression of estrogen receptor (ESR1) in cartilage and bone, whereas androgen receptor (AR) expression appeared to be restricted to bone. Nevertheless, with respect to osteoarticular metabolism, steroid hormone deprivation resulting from early castration had no discernable impact on the levels of biomarkers related to bone and cartilage metabolism, nor on those associated with OA and inflammation. Consequently, our research demonstrated that early castration does not disrupt bone and cartilage homeostasis.
Fichier principal
Vignette du fichier
ijms-24-16778 rouge.pdf (4.62 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04312304 , version 1 (14-12-2023)

Licence

Paternité

Identifiants

Citer

Marion Rouge, Florence Legendre, Razan Elkhatib, Christelle Delalande, Juliette Cognie, et al.. Early castration in horses does not impact osteoarticular metabolism. International Journal of Molecular Sciences, 2023, 24 (23), pp.16778. ⟨10.3390/ijms242316778⟩. ⟨hal-04312304⟩
45 Consultations
14 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More