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Article Dans Une Revue Journal of Experimental Medicine Année : 2023

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Aurélien Sokal
Paul Bastard
Pascal Chappert
Giovanna Barba-Spaeth
Slim Fourati
Alexis Vanderberghe
Pauline Lagouge-Roussey
Isabelle Meyts
Adrian Gervais
Magali Bouvier-Alias
Imane Azzaoui
Ignacio Fernández
Andréa de la Selle
Qian Zhang
Lucy Bizien
Isabelle Pellier
Agnès Linglart
Anya Rothenbuhler
Estelle Marcoux
Raphael Anxionnat
Nathalie Cheikh
Juliane Léger
Blanca Amador-Borrero
  • Fonction : Auteur
Fanny Fouyssac
  • Fonction : Auteur
Vanessa Menut
Jean-Christophe Goffard
Caroline Storey
Caroline Demily
Coralie Mallebranche
Jesus Troya
Aurora Pujol
Marie Zins
Pierre Tiberghien
Paul Gray
Peter Mcnaughton
Anna Sullivan
  • Fonction : Auteur
Jane Peake
Romain Levy
Laetitia Languille
Carlos Rodiguez-Gallego
  • Fonction : Auteur
Bertrand Boisson
Sébastien Gallien
Bénédicte Neven
Marc Michel
  • Fonction : Auteur
Bertrand Godeau
Laurent Abel
Felix Rey
Jean-Claude Weill
Claude-Agnès Reynaud
Stuart Tangye
Jean-Laurent Casanova
Matthieu Mahévas

Résumé

Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)–specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines.

Dates et versions

hal-04311372 , version 1 (28-11-2023)

Identifiants

Citer

Aurélien Sokal, Paul Bastard, Pascal Chappert, Giovanna Barba-Spaeth, Slim Fourati, et al.. Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination. Journal of Experimental Medicine, 2023, 220 (1), ⟨10.1084/jem.20220258⟩. ⟨hal-04311372⟩
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