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Communication Dans Un Congrès Année : 2023

The level of methionine deficiency determines its effects on energy metabolism in growing rats.

Résumé

Methionine deficiency has been reported as beneficial for health. Indeed, despite an increase in energy intake, it increases energy expenditure and improves insulin sensitivity, which in turn lowers blood lipids and adiposity. However, when fed to young animals, these effects are followed by a growth retardation. In the majority of studies, the consequences of methionine restriction have been studied on the same level of intake. Thus, the aim of this study is to characterize the effects of multiple methionine deficient levels on growth and energy metabolism in growing rats. Growing rats were fed for 3 weeks a control diet (P20; 20% of proteins; 100% of methionine requirement) or diets with gradual deficiency levels, ie 15, 25, 40, 60, 75 % of methionine requirement. Body weight and food intake (FI) were daily measured, energy expenditure (EE) was measured by indirect calorimetry, and body composition was determined by the weighting of the main tissues and organs. Body weight was analyzed by repeated measures mixt model, and other variables by one-way ANOVA. Growing rats fed methionine-deficient diets increased their FI, probably to compensate for the methionine deficiency unless the latter is too severe (15%). However, the compensation was only partial and was not sufficient to prevent the decrease in weight gain, mainly reflected by a reduced lean body mass for severely to moderately deficient diets (15, 25, 40%). In the absence of dietary compensation (15%), fat mass was also decreased. The increase in FI was maximal for the 60% diet (by mesenteric, retroperitoneal, and subcutaneous adipose tissue). Rats subjected to a moderate deficiency (40 and 60%) increased their EE (through their resting EE), allowing them to expend the excess energy consumed. However, this does not seem to be sufficient for the 60% rats, which have an increase in body fat. This study shows that the level of methionine deficiency is crucial to understand its effects in young rats. For a severe deficiency, FI can not compensate Methionine deficiency and growth retardation whereas for moderate level of methionine deficiency, the FI increased and EE can not compensate the excess of energy intake.
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Dates et versions

hal-04311205 , version 1 (28-11-2023)

Identifiants

  • HAL Id : hal-04311205 , version 1

Citer

Gaëtan Roisné-Hamelin, Céline Cansell, Catherine C. Chaumontet, Anne Blais, Julien Piedcoq, et al.. The level of methionine deficiency determines its effects on energy metabolism in growing rats.. 14th European Nutrition Conference (ENC) FENS 2023, Nov 2023, Belgrade (Serbia), Serbia. ⟨hal-04311205⟩
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