A Phosphine Oxide-Functionalized Cyclam as a Specific Copper(II) Chelator - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Inorganic Chemistry Année : 2023

A Phosphine Oxide-Functionalized Cyclam as a Specific Copper(II) Chelator

Résumé

Although cyclam-based ligands are among the strongest copper(II) chelators available, they also usually present good affinity for other divalent cations [Zn(II), Ni(II), and Co(II)], with no copper(II)-specific cyclam ligands having been described so far. As such a property is highly desirable in a wide range of applications, we present herein two novel phosphine oxide-appended cyclam ligands that could be efficiently synthesized through Kabachnik–Fields type reactions on protected cyclam precursors. Their copper(II) coordination properties were closely studied by different physicochemical techniques [electron paramagnetic resonance (EPR) and ultraviolet–visible (UV–vis) spectroscopies, X-ray diffraction, and potentiometry]. The mono(diphenylphosphine oxide)-functionalized ligand demonstrated a copper(II)-specific behavior, unprecedented within the cyclam family of ligands. This was evidenced by UV–vis complexation and competition studies with the parent divalent cations. Density functional theory calculations also confirmed that the particular ligand geometry in the complexes strongly favors copper(II) coordination over that of competing divalent cations, rationalizing the specificity observed experimentally.
Fichier principal
Vignette du fichier
Le Roy et al - final manuscript - Inorg Chem.pdf (1002.3 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04308620 , version 1 (30-08-2024)

Identifiants

Citer

Marie Le Roy, Simon Héry, Nathalie Saffon-Merceron, Carlos Platas-Iglesias, Thibault Troadec, et al.. A Phosphine Oxide-Functionalized Cyclam as a Specific Copper(II) Chelator. Inorganic Chemistry, 2023, 62 (21), pp.8112-8122. ⟨10.1021/acs.inorgchem.3c00329⟩. ⟨hal-04308620⟩
21 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More