NanOx-based multiscale modeling of the biological dose in BNCT to estimate the impact of boron microdistributions - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2023

NanOx-based multiscale modeling of the biological dose in BNCT to estimate the impact of boron microdistributions

Résumé

BNCT is a promising therapy for bad prognosis tumors like glioblastoma or recurrent head and neck cancer. The benefit of BNCT relies on both the boron targeting into the tumor and the biological effectiveness of the low-energy ions following the neutron capture. Biological dose modeling is therefore required in order to optimize the treatment plans. Several formalisms have been presented over the years but they do not consider the microdistribution of boron that should strongly impact tumor control probability (TCP). The present study aims at quantifying this impact using multiscale modeling and consideration of biological effect due to each secondary particle instead of weighting factors. The scales range from nanometers, through the biophysical model NanOx, up to the patient for which the resolution is defined by the voxel size. NanOx has proven its accuracy to describe the cell response under several ion-type irradiations of interest for hadrontherapy. Our multiscale methodology can be decomposed in 4 stages: -Modeling of multicellular geometry and various scenarios of intracellular boron distributions; -For these scenarios, pre-calculations of biological coefficients with NanOx for several cell lines; -In each voxel of the patient CT scan, calculations by Monte Carlo simulations of the dose deposited by gammas, the energy spectra of recoil protons and the concentration of neutron captures by boron; -Calculation of 3D biological dose distributions and TCP by combining the outcomes from the two previous stages. Comparisons will be done with existing BNCT formalisms and various neutron spectra. Preliminary results will be presented for simplified BNCT irradiation conditions.
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Dates et versions

hal-04305506 , version 1 (24-11-2023)

Identifiants

  • HAL Id : hal-04305506 , version 1

Citer

Maria Pedrosa Rivera, Rachel Delorme, Victor Levrague, Sarah Otmani, Mario Alcocer-Avila, et al.. NanOx-based multiscale modeling of the biological dose in BNCT to estimate the impact of boron microdistributions. 61st Annual PTCOG Conference, Jun 2023, Madrid, Spain. . ⟨hal-04305506⟩
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