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Article Dans Une Revue Environment International Année : 2022

In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts

1 UPF - Universitat Pompeu Fabra [Barcelona]
2 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam
3 Keck School of Medicine [Los Angeles]
4 IDIAPJGol - Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina
5 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Centro de Investigación Biomédica, University of Granada, Granada
6 NIPH - Norwegian Institute of Public Health [Oslo]
7 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain; Department of Statistics and Operational Research. Universitat de València. València
8 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam
9 Departments of Pediatrics and Environmental Medicine, New York University School of Medicine, New York, NY
10 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Preventive medicine and public health department, University of Basque Country (UPV/EHU), Leioa, Spain; Biodonostia Health research institute, Donostia-San Sebastian
11 Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain; Faculty of Nursing and Chiropody, University of Valencia, Valencia
12 University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Grenoble
13 Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete
14 ibs.GRANADA Instituto de Investigación Biosanitaria [Granada, Spain]
15 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
16 Paediatrics Service, Hospital Zumarraga, Gipuzkoa
17 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Division of Neonatology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam

Résumé

Methods: We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted randomeffects meta-analysis on individual participant data. Results: Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (pinteraction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. Conclusion: This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls.
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hal-04302866 , version 1 (23-11-2023)

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Alicia Abellan, Sara M Mensink-Bout, Raquel Garcia-Esteban, Andrea Beneito, Leda Chatzi, et al.. In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts. Environment International, 2022, 162 (8), pp.107178. ⟨10.1016/j.envint.2022.107178⟩. ⟨hal-04302866⟩
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