Mechanical DNA Origami to Investigate Biological Systems - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Advanced Biology Année : 2023

Mechanical DNA Origami to Investigate Biological Systems

Allan Mills
  • Fonction : Auteur
Julie Finkel
  • Fonction : Auteur
Gaëtan Bellot

Résumé

Abstract The ability to self‐assemble DNA nanodevices with programmed structural dynamics that can sense and respond to the local environment can enable transformative applications in fields including mechanobiology and nanomedicine. The responsive function of biomolecules is often driven by alterations in conformational distributions mediated by highly sensitive interactions with the local environment. In this review, the current state‐of‐the‐art in constructing complex DNA geometries with dynamic and mechanical properties to enable a molecular scale force measurement is first summarized. Next, an overview of engineering modular DNA devices that interact with cell surfaces is highlighted detailing examples of mechanosensitive proteins and the force‐induced dynamic molecular interaction on the downstream biochemical signaling. Finally, the challenges and an outlook on this promising class of DNA devices acting as nanomachines to operate at a low piconewton range suitable for a majority of biological effects or as hybrid materials to achieve higher tension exertion required for other biological investigations, are discussed.
Fichier principal
Vignette du fichier
mechanical_origami.pdf (1.02 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04298530 , version 1 (21-11-2023)

Identifiants

Citer

Allan Mills, Nesrine Aissaoui, Julie Finkel, Juan Elezgaray, Gaëtan Bellot. Mechanical DNA Origami to Investigate Biological Systems. Advanced Biology, 2023, 7 (3), ⟨10.1002/adbi.202200224⟩. ⟨hal-04298530⟩
14 Consultations
13 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More