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Article Dans Une Revue Genes and Cancer Année : 2023

Leveraging a powerful allogeneic dendritic cell line towards neoantigen-based cancer vaccines

Résumé

In recent years, immunotherapy has finally found its place in the anti-cancer therapeutic arsenal, even becoming standard of care as first line treatment for metastatic forms. The clinical benefit provided by checkpoint blockers such as anti-PD-1/PD-L1 in many cancers revolutionized the field. However, too many patients remain refractory to these treatments due to weak baseline anti-cancer immunity. There is therefore a need to boost the frequency and function of patients' cytotoxic CD8+ cellular effectors by targeting immunogenic and tumor-restricted antigens, such as neoantigens using an efficient vaccination platform. Dendritic cells (DC) are the most powerful immune cell subset for triggering cellular immune response. However, autologous DC-based vaccines display several limitations, such as the lack of reproducibility and the limited number of cells that can be manufactured. Here we discuss the advantages of a new therapeutic vaccine based on an allogeneic Plasmacytoid DC cell line, which is easy to produce and represents a powerful platform for priming and expanding anti-neoantigen cytotoxic CD8+ T cells.
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hal-04297113 , version 1 (21-11-2023)

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Dalil Hannani, Estelle Leplus, Karine Laulagnier, Laurence Chaperot, Joël Plumas. Leveraging a powerful allogeneic dendritic cell line towards neoantigen-based cancer vaccines. Genes and Cancer, 2023, 14, pp.3-11. ⟨10.18632/genesandcancer.229⟩. ⟨hal-04297113⟩

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