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Article Dans Une Revue International Archives of Occupational and Environmental Health Année : 2023

Association between household cleaning product exposure in infancy and development of recurrent wheeze and asthma

Isis Felippe Baroni
  • Fonction : Auteur
Geneva D. Mehta
  • Fonction : Auteur
Ashley F. Sullivan
  • Fonction : Auteur
Carlos Arturo Camargo Jr
  • Fonction : Auteur

Résumé

Objective: Household chemicals may act as irritants in the lungs; however, their association with recurrent wheeze and asthma in children remains controversial. We aimed to investigate if household cleaning product exposure in infancy is associated with recurrent wheezing and asthma development in children. Methods: We analyzed data from two cohorts: MARC-35 consisting of 815 children with history of severe bronchiolitis in infancy, and MARC-43 consisting of 525 healthy children in infancy. Frequency of use of cleaning product at the child’s home during infancy was collected via telephone interview with parents. Outcomes were recurrent wheezing by age 3 years and asthma diagnosis at age 6 years. Results: In MARC-35, there was no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR = 1.01 [95% CI 0.66–1.54] for 4–7 days/week exposure frequency), nor asthma (adjusted OR = 0.91 [95% CI 0.51–1.63]). In MARC-43, there was also no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR = 0.69 [95% CI 0.29–1.67] for 4–7 days/week exposure frequency). Conclusion: We found no association between household cleaning product exposure in infancy and later development of recurrent wheeze or asthma, even among children who are at high risk for asthma due to history of severe bronchiolitis.
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Dates et versions

hal-04294679 , version 1 (20-11-2023)

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Isis Felippe Baroni, Geneva D. Mehta, Ashley F. Sullivan, Carlos Arturo Camargo Jr, Orianne Dumas. Association between household cleaning product exposure in infancy and development of recurrent wheeze and asthma. International Archives of Occupational and Environmental Health, 2023, 96 (10), pp.1325-1332. ⟨10.1007/s00420-023-02011-5⟩. ⟨hal-04294679⟩
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