The improvements in living standards and air-conditioning have widely been applied, however, the health effects of indoor air pollution have been increasing, especially in the last three years with the coronavirus. To get clean air through the building, filtration is one of the most efficient strategies to optimize indoor air quality. In this regard, a comparative study was done in a classroom at ENTPE laboratory to emphasize filtration’s importance and to test the efficiency of analyzed type PM10_50. The results highlighted allows us to see the impact of control strategy on the efficiency of filtration (air conditions and ventilation systems performances). The numerical feedback has also been analyzed and the results allowed us to find an efficient filter and draw recommendations for their use.