Transport and mobility systems are historically deeply influenced by the context, including legislation, operation arrangements, decision-making process, users’ behaviours, and travel modals. With a great expectation to change what is known, mobility innovations aim to offer a better arrangement towards a more sustainable, efficient, safer, and economical, technological, and spatial accessible. A suitable definition of governance processes is required to achieve positive results. In this sense, based on the responsible innovation (RI) approach, this paper aims to propose a responsible urban mobility system. The applied methodology is based on an integrative review supported by content analysis. The main discussion of this paper is directed to propose that the urban mobility system should be implemented in a responsible way. As a result, a concept of a responsible urban mobility system is proposed based on governance definitions sustained by RI's premises. Responsibility in urban mobility systems comes from a governance system founded on new ways of planning, coordination, and management of complexities and uncertainties, taking cities as particular contexts.