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Article Dans Une Revue Behavioural Brain Research Année : 2024

Behavioural characteristics and sex differences of a treatment-resistant depression model: Chronic mild stress in the Wistar-Kyoto rat

Vincent Loizeau
  • Fonction : Auteur
Laura Durieux
  • Fonction : Auteur
Jorge Mendoza
  • Fonction : Auteur
Ove Wiborg
  • Fonction : Auteur
Alexandra Barbelivien
  • Fonction : Auteur

Résumé

The lateral habenula (LHb) is an epithalamic brain region viewed as a converging hub, integrating information from a large connectome and then projecting to few critical midbrain monoaminergic systems. Numerous studies have explored the roles of the LHb, notably in aversion and avoidance. An important recurring finding when manipulating the LHb is the induction of anxiety-related behaviours. However, its exact role in such behaviours remains poorly understood. In the present study, we used two pharmacological approaches altering LHb activity, intra-LHb infusion of either the GABA-A receptor agonist, Muscimol, or the glutamatergic AMPA receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and exposed rats to three consecutive open field (OF) sessions. We found that both pharmacological treatments prevented rats to explore the centre of the OF, considered as the most anxiogenic part of the apparatus, across the three OF sessions. In addition, during the first, but not the two consecutive sessions, both treatments prevented a thorough exploration of the OF. Altogether, these results confirm the crucial role played by the LHb in anxiety-related behaviours and further suggest its implication in the exploration of new anxiogenic environments.
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Dates et versions

hal-04286853 , version 1 (24-11-2023)

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Vincent Loizeau, Laura Durieux, Jorge Mendoza, Ove Wiborg, Alexandra Barbelivien, et al.. Behavioural characteristics and sex differences of a treatment-resistant depression model: Chronic mild stress in the Wistar-Kyoto rat. Behavioural Brain Research, In press, 457, pp.114712. ⟨10.1016/j.bbr.2023.114712⟩. ⟨hal-04286853⟩

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