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Article Dans Une Revue Epidemiology Année : 2023

Meconium concentrations of pesticides and risk of hypospadias: a case–control study in Brittany, France

Résumé

Background: Hypospadias is a male genital tract defect for which an increase in prevalence has been documented over the last few decades. A role environmental risk factors suspected, including prenatal exposure to pesticides. Objectives: To study of hypospadias association with multiple pesticide measurements meconium samples. Methods: The Brittany Registry Congenital Anomalies (France) conducted case–control between 2012 and 2018. Cases were hypospadias, ascertained by pediatrician pediatric surgeon, excluding genetic conditions, following EUROCAT guidelines (N=69). Controls (N=135) two infants without congenital anomaly born after each case same maternity unit. Mothers units completed self-administered questionnaire, we collected medical data from hospital records, staff We performed chemical analysis 38 pesticides (parent compound and/or metabolite) UHPLC/MS/MS strict quality assurance/quality control criteria blind status. carried out logistic regression accounting frequency-matching variables major factors. Results: Among measured, 16 (42%) never detected samples, 18 (47%) andlt
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hal-04286565 , version 1 (15-11-2023)

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Florence Rouget, Adele Bihannic, Barbara Le Bot, Fabien Mercier, Erwann Gilles, et al.. Meconium concentrations of pesticides and risk of hypospadias: a case–control study in Brittany, France. Epidemiology, 2023, ⟨10.1097/ede.0000000000001688⟩. ⟨hal-04286565⟩
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