Model of membrane deformations driven by a surface <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>p</mml:mi><mml:mi mathvariant="normal">H</mml:mi></mml:mrow></mml:math> gradient - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Physical Review E Année : 2023

Model of membrane deformations driven by a surface pH gradient

Toni V Mendes
Jonas Ranft
Hélène Berthoumieux

Résumé

Many cellular organelles are membrane-bound structures with complex membrane composition and shape. Their shapes have been observed to depend on the metabolic state of the organelle and the mechanisms that couple biochemical pathways and membrane shape are still actively investigated. Here, we study a model coupling inhomogeneities in the lipid composition and membrane geometry via a generalized Helfrich free energy. We derive the resulting stress tensor, the Green's function for a tubular membrane, and compute the phase diagram of the induced deformations. We then apply this model to study the deformation of mitochondria cristae described as membrane tubes supporting a pH gradient at its surface. This gradient in turn controls the lipid composition of the membrane via the protonation or deprotonation of cardiolipins, which are acid-based lipids known to be crucial for mitochondria shape and functioning. Our model predicts the appearance of tube deformations resembling the observed shape changes of cristea when submitted to a proton gradient.
Fichier principal
Vignette du fichier
PhysRevE.108.014113.pdf (749.97 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04285967 , version 1 (14-11-2023)

Identifiants

Citer

Toni V Mendes, Jonas Ranft, Hélène Berthoumieux. Model of membrane deformations driven by a surface pH gradient. Physical Review E , 2023, 108, ⟨10.1103/physreve.108.014113⟩. ⟨hal-04285967⟩
17 Consultations
9 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More