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Article Dans Une Revue Journal of Virology Année : 2023

SARS-CoV-2 replicates in the human testis with slow kinetics and has no major deleterious effects ex vivo

Olivier Schwartz

Résumé

SARS-CoV-2, the etiological agent of the ongoing Covid-19 pandemic, is a respiratory virus that infects several organs beyond the lungs. The alterations of semen parameters, testicular morphology, and testosteronemia reported in Covid-19 patients, along with the high expression of SARS-CoV-2 main receptor ACE2 in the testis, raise questions about the underlying mechanisms. Using a previously validated ex vivo model of human testis, we show that SARS-CoV-2 infects ACE2-positive Leydig and Sertoli cells. Slow virus replication kinetics were observed, with a peak of infection at day 6 post-infection and a decline of infectious virions at day 9. The infection had no major impact on testicular morphology or main hormonal functions, but some steroidogenic enzymes were decreased at day 9. While antiviral effectors were upregulated, there was no transcriptional induction of key pro-inflammatory cytokines. Altogether, these data indicate that SARS-CoV-2 replication in the human testis ex vivo is limited and suggest that testicular damages in infected individuals are unlikely to result from direct deleterious effects of SARS-CoV-2 on this organ.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-04285464 , version 1 (15-11-2023)

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Paternité

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Dominique Mahé, Salomé Bourgeau, Janaina da Silva, Julie Schlederer, Anne-Pascale Satie, et al.. SARS-CoV-2 replicates in the human testis with slow kinetics and has no major deleterious effects ex vivo. Journal of Virology, 2023, 97 (10), pp.01104-23. ⟨10.1128/jvi.01104-23⟩. ⟨hal-04285464⟩
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