Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA - Archive ouverte HAL
Article Dans Une Revue Comptes Rendus. Chimie Année : 2023

Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA

Résumé

Tetrameric DNA structures such as G-quadruplex (G4) and i-motif (i-DNA) have attracted increasing interest in the last decades. They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4-and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. This review reports on our works over the past decade.
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Dates et versions

hal-04278512 , version 1 (10-11-2023)

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Jérôme Dejeu, Eric Defrancq. Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA. Comptes Rendus. Chimie, 2023, 26 (1), pp.1 - 14. ⟨10.5802/crchim.256⟩. ⟨hal-04278512⟩
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