TRPs and Ca2+ in cell death and survival - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Calcium Année : 2018

TRPs and Ca2+ in cell death and survival

Résumé

Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to environmental stimuli. Pharmacological or genetic manipulations of TRP channels demonstrate that TRP channels influence cell death rates, prolonging or shortening of cell survival. Due to their diverse cellular localization, TRP channels mediated Ca2+ influx generates distinct intracellular Ca2+ signals that regulate downstream pathways converging to apoptosis or survival. In this review, we summarize the accumulated knowledge focused on how TRP channel regulate cell fate and may affect different pathologies including cardiovascular, neurological, metabolic or neoplastic disorders.
Fichier non déposé

Dates et versions

hal-04277367 , version 1 (09-11-2023)

Identifiants

Citer

Ingrid Fliniaux, Emmanuelle Germain, Valerio Farfariello, Natalia Prevarskaya. TRPs and Ca2+ in cell death and survival. Cell Calcium, 2018, 69, pp.4-18. ⟨10.1016/j.ceca.2017.07.002⟩. ⟨hal-04277367⟩
12 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More