Biological fractionation of lithium isotopes by cellular Na + /H + exchangers unravels fundamental transport mechanisms - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue iScience Année : 2023

Biological fractionation of lithium isotopes by cellular Na + /H + exchangers unravels fundamental transport mechanisms

Résumé

Lithium (Li) has a wide range of uses in science, medicine, and industry, but its isotopy is underexplored, except in nuclear science and in geoscience. 6 Li and 7 Li isotopic ratio exhibits the second largest variation on earth's surface and constitutes a widely used tool for reconstructing past oceans and climates. As large variations have been measured in mammalian organs, plants or marine species, and as 6 Li elicits stronger effects than natural Li ($95% 7 Li), a central issue is the identification and quantification of biological influence of Li isotopes distribution. We show that membrane ion channels and Na +-Li + /H + exchangers (NHEs) fractionate Li isotopes. This systematic 6 Li enrichment is driven by membrane potential for channels, and by intracellular pH for NHEs, where it displays cooperativity, a hallmark of dimeric transport. Evidencing that transport proteins discriminate between isotopes differing by one neutron opens new avenues for transport mechanisms, Li physiology, and paleoenvironments.
Fichier principal
Vignette du fichier
iScience 2023.pdf (3.81 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04275505 , version 1 (08-11-2023)

Identifiants

Citer

Mallorie Poet, Nathalie Vigier, Yann Bouret, Gisele Jarretou, Romain Gautier, et al.. Biological fractionation of lithium isotopes by cellular Na + /H + exchangers unravels fundamental transport mechanisms. iScience, 2023, 26 (6), ⟨10.1016/j.isci.2023.106887⟩. ⟨hal-04275505⟩
22 Consultations
8 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More