Structure of a DNA G-quadruplex that modulates SP1 binding sites architecture in HIV-1 promoter
Résumé
Nucleic acid sequences containing guanine tracts can form G-quadruplexes (G4s), impacting gene regulation. • Principal results: HIVpro2 DNA sequence, derived from the HIV-1 promoter, forms a hybrid G4 structure with a single-nucleotide bulge. HIVpro2 G4 can modulate SP1 binding sites architecure, potentially regulating viral transcription and latency. • Conceptual advance: Discovery of a G4 structure in HIVpro2 suggests a novel mechanism for HIV-1 gene regulation. • Significance: Understanding the structural switch between G4s and canonical duplexes may offer new strategies for HIV-1 therapy and latency control.
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