Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion

Résumé

Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this study, we identified non-steroidal estrogens as potent inhibitors of influenza virus due to their interaction with the hemagglutinin protein, preventing viral entry. This activity is maintained in vitro, ex vivo, and in vivo. Therefore, we found a new domain to target on the hemagglutinin and a class of compounds that could be further optimized for influenza treatment.
Fichier principal
Vignette du fichier
ijms-24-15382-v2.pdf (3.31 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04271263 , version 1 (10-11-2023)

Licence

Paternité

Identifiants

Citer

Elisa Franzi, Gregory Mathez, Soraya Dinant, Charlotte Deloizy, Laurent K. Kaiser, et al.. Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion. International Journal of Molecular Sciences, 2023, 24 (20), pp.15382. ⟨10.3390/ijms242015382⟩. ⟨hal-04271263⟩
29 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More