Trimethoxyarene as a Highly Ionizable Tag for Reaction Analysis by Atmospheric Pressure Photoionization Mass Spectrometry (APPI/MS): Exploration of Heterocyclic Synthesis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2012

Trimethoxyarene as a Highly Ionizable Tag for Reaction Analysis by Atmospheric Pressure Photoionization Mass Spectrometry (APPI/MS): Exploration of Heterocyclic Synthesis

Résumé

Abstract A mass spectrometry (MS) method was developed to rapidly analyze crude reaction mixtures. This method relies on highly effective ionization by atmospheric pressure photoionization (APPI) of molecules with a prosthetic trimethoxyarene (TMOA) residue. In a crude reaction mixture, products resulting from the reaction of the TMOA‐labeled substrate will be selectively ionized to afford an easily readable mass spectrum. Interestingly, we noticed that TMOA‐labeled molecules were not fragmented and gave the preferred [M + H] + ion peak. This APPI‐MS reaction mixture analysis method was used for the optimization of heterocycle synthesis. By comparing results obtained by APPI/MS, GC, and HPLC analysis, it appeared that a semi‐quantification could be achieved by integrating the MS peak intensities.

Domaines

Chimie

Dates et versions

hal-04270217 , version 1 (03-11-2023)

Identifiants

Citer

Mathieu Bui The Thuong, Cédric Catala, Cyril Colas, Christine Schaeffer, Alain van Dorsselaer, et al.. Trimethoxyarene as a Highly Ionizable Tag for Reaction Analysis by Atmospheric Pressure Photoionization Mass Spectrometry (APPI/MS): Exploration of Heterocyclic Synthesis. European Journal of Organic Chemistry, 2012, 2012 (1), pp.85-92. ⟨10.1002/ejoc.201100919⟩. ⟨hal-04270217⟩
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