Arsenic hypertolerance in the protist Euglena mutabilis is mediated by specific transporters and functional integrity maintenance mechanisms - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Environmental Microbiology Année : 2015

Arsenic hypertolerance in the protist Euglena mutabilis is mediated by specific transporters and functional integrity maintenance mechanisms

Résumé

Summary Arsenic is a toxic metalloid known to cause multiple and severe cellular damages, including lipid peroxidation, protein misfolding, mutagenesis and double and single‐stranded DNA breaks. Thus, exposure to this compound is lethal for most organisms but some species such as the photosynthetic protist E uglena mutabilis are able to cope with very high concentrations of this metalloid. Our comparative transcriptomic approaches performed on both an arsenic hypertolerant protist, i.e. E . mutabilis , and a more sensitive one, i.e. E . gracilis , revealed multiple mechanisms involved in arsenic tolerance. Indeed, E . mutabilis prevents efficiently the accumulation of arsenic in the cell through the expression of several transporters. More surprisingly, this protist induced the expression of active DNA reparation and protein turnover mechanisms, which allow E . mutabilis to maintain functional integrity of the cell under challenging conditions. Our observations suggest that this protist has acquired specific functions regarding arsenic and has developed an original metabolism to cope with acid mine drainages‐related stresses.

Dates et versions

hal-04268070 , version 1 (02-11-2023)

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David Halter, Jérémy Andres, Frédéric Plewniak, Julie Poulain, Corinne da Silva, et al.. Arsenic hypertolerance in the protist Euglena mutabilis is mediated by specific transporters and functional integrity maintenance mechanisms. Environmental Microbiology, 2015, 17 (6), pp.1941-1949. ⟨10.1111/1462-2920.12474⟩. ⟨hal-04268070⟩
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