Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Allergy Année : 2019

Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France

Mathieu Molimard
Xavier Ansolabehere
  • Fonction : Auteur
Isabelle Bardoulat
  • Fonction : Auteur
Nicolas Coulombel
  • Fonction : Auteur
Frédérique Maurel
  • Fonction : Auteur
Philippe Le Jeunne
  • Fonction : Auteur
Pascal Demoly
  • Fonction : Auteur

Résumé

Abstract Background Moderate‐to‐severe allergic rhinitis ( AR ) may increase the risk of developing or worsening asthma, whereas treatment of AR with subcutaneously or sublingual allergen immunotherapy ( SLIT ) may slow this progression. Methods In a retrospective real‐world analysis, prescription fulfilment data were gathered from French retail pharmacies between 1 March 2012 and 31 December 2016. Using linear regression analyses, patients having received at least two prescriptions of grass pollen SLIT tablets over at least 2 successive years were compared with control patients having received symptomatic medications only. Results A total of 1099 SLIT patients and 27 475 control patients were included in the main analysis. With regard to symptomatic AR medication dispensing, we observed a 50% decrease in the pre‐index/follow‐up ratio in the SLIT group, a 30% increase in the control group without age matching ( P < 0.0001 vs SLIT ) and a 20% increase in the control group with age matching ( P < 0.0001 vs SLIT ). During the follow‐up, 11 (1.8%) and 782 (5.3%) patients initiated asthma treatment in the SLIT and control groups, respectively. The relative risk of medication dispensing for new asthma was lower in the SLIT group (by 62.5% [29.1%‐80.1%] without age matching ( P = 0.0025) and by 63.7% [31.5%‐80.7%] with age matching; P = 0.0018). SLIT was also associated with slower progression of asthma medication dispensing during the follow‐up period, relative to the control group (regression coefficient: −0.58 [−0.74 to 0.42] without age matching ( P < 0.0001) and −0.61 [−0.76 to −0.46] with age matching; P < 0.0001). Conclusion Prescription of grass pollen SLIT tablets reduced the dispensing of AR and asthma medications in real life.
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Dates et versions

hal-04265190 , version 1 (30-10-2023)

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Philippe Devillier, Mathieu Molimard, Xavier Ansolabehere, Isabelle Bardoulat, Nicolas Coulombel, et al.. Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France. Allergy, 2019, 74 (7), pp.1317-1326. ⟨10.1111/all.13705⟩. ⟨hal-04265190⟩
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