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Article Dans Une Revue Chem Année : 2023

Nature-inspired synthetic oligourea foldamer channels allow water transport with high salt rejection

Gavin W Collie
  • Fonction : Auteur

Résumé

Short helical amphipathic oligourea foldamers were designed with distinct hydrophobic and hydrophilic faces. Two of the foldamers (H2OC1 and H2OC2) obtained by solid phase synthesis self-assembled into channel-type nanostructures that show efficient water permeability across lipid membranes while rejecting ions. A self-assembled quaternary structure with two superhelical scaffolds results in the formation of 4.8 and 6.4 A ˚inner pores that were observed in the crystal packing of H2OC1. Both pores have hydrophilic interior and hydrophobic exterior surfaces. Our findings demonstrate the channel-forming ability of oligourea foldamers in lipid bilayers, and such novel artificial water channels could be beneficial for water purification applications.
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Dates et versions

hal-04257802 , version 1 (27-10-2023)

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Chiranjit Dutta, Pannaga Krishnamurthy, Dandan Su, Sung Hyun Yoo, Gavin W Collie, et al.. Nature-inspired synthetic oligourea foldamer channels allow water transport with high salt rejection. Chem, 2023, 9 (8), pp.2237-2254. ⟨10.1016/j.chempr.2023.04.007⟩. ⟨hal-04257802⟩
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