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Article Dans Une Revue Journal of Experimental Medicine Année : 2021

Activated microglia mitigate Aβ-associated tau seeding and spreading

Yun Chen
Samira Parhizkar
Nimansha Jain
Michael Strickland
Javier Remolina Serrano
Marco Colonna
Jason Ulrich
David Holtzman

Résumé

In Alzheimer’s disease (AD) models, AD risk variants in the microglial-expressed TREM2 gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well as plaque-associated seeding and spreading of tau aggregates. Whether this Aβ-enhanced tau seeding/spreading is due to loss of microglial function or a toxic gain of function in TREM2-deficient microglia is unclear. Depletion of microglia in mice with established brain amyloid has no effect on amyloid but results in less spine and neuronal loss. Microglial repopulation in aged mice improved cognitive and neuronal deficits. In the context of AD pathology, we asked whether microglial removal and repopulation decreased Aβ-driven tau seeding and spreading. We show that both TREM2KO and microglial ablation dramatically enhance tau seeding and spreading around plaques. Interestingly, although repopulated microglia clustered around plaques, they had a reduction in disease-associated microglia (DAM) gene expression and elevated tau seeding/spreading. Together, these data suggest that TREM2-dependent activation of the DAM phenotype is essential in delaying Aβ-induced pathological tau propagation.

Dates et versions

hal-04256733 , version 1 (24-10-2023)

Identifiants

Citer

Maud Gratuze, Yun Chen, Samira Parhizkar, Nimansha Jain, Michael Strickland, et al.. Activated microglia mitigate Aβ-associated tau seeding and spreading. Journal of Experimental Medicine, 2021, 218 (8), ⟨10.1084/jem.20210542⟩. ⟨hal-04256733⟩
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