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Article Dans Une Revue Progress in Neuro-Psychopharmacology and Biological Psychiatry Année : 2023

Behavioral sensitization to psychostimulants and opioids: What is known in rodents and what still needs to be explored in humans?

Résumé

Repeated exposure to substances of abuse results in an increase in some behavioral responses. This phenomenon, called behavioral sensitization (BS), is well described in preclinical models However, its existence in humans is still a matter of debate. After a review of preclinical evidence of BS and its mechanisms in animal models, we reviewed the evidence supporting the existence of BS in humans, despite the limited research available in this regard. We focused our review on opioids and psychostimulants, since they share the ability to promote addictive behaviors. Further, they induce BS despite their distinct sedative and stimulant properties. Moreover, we proposed future research perspectives in this review to address the remaining unsolved questions, especially regarding BS in humans using a harm reduction approach.
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hal-04255876 , version 1 (08-12-2023)

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Clément Delage, Alix Morel, Pauline de Witt, Marie Jauffret-Roustide, Vanessa Bloch, et al.. Behavioral sensitization to psychostimulants and opioids: What is known in rodents and what still needs to be explored in humans?. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2023, 127, pp.110824. ⟨10.1016/j.pnpbp.2023.110824⟩. ⟨hal-04255876⟩
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