Curvature gradient drives polarized tissue flow in the Drosophila embryo
Résumé
Significance Much is known about how genetic prepatterning of the embryo defines the initial instructions for morphogenesis, but how these instructions are deployed in a specific mechanical and geometrical environment is unknown. In our manuscript, we use Drosophila embryos to explore how genetics, mechanics, and geometry interact to drive polarized (directional) tissue flow. Through a combination of experimental and modeling approaches, we show that previously proposed mechanisms cannot account for the tissue flows observed during the early stages of Drosophila morphogenesis. Instead, we reveal a mechanism whereby polarized flows arise from the interaction between myosindriven tissue contraction and the curvature of the tissue imposed by the shape of the egg.
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Licence : Copyright (Tous droits réservés)