Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model
Résumé
Our results highlighted that force production decreases between 2 and 4 mo of age in SCD mice thereby indicating a decrease of muscle function during this period. Of interest, HU treatment seemed to blunt the observed age effect given that SCD 4 m-HU mice displayed a higher specific force production as compared with SCD 4 m mice. In that respect, HU treatment would help to maintain a higher capacity of force production during aging in SCD.
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Hydroxyurea_SKM_energetics_function_SCD_mice_MICHEL_HAL.pdf (958.72 Ko)
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Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification