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Article Dans Une Revue Journal of Applied Physiology Année : 2023

Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model

Résumé

Our results highlighted that force production decreases between 2 and 4 mo of age in SCD mice thereby indicating a decrease of muscle function during this period. Of interest, HU treatment seemed to blunt the observed age effect given that SCD 4 m-HU mice displayed a higher specific force production as compared with SCD 4 m mice. In that respect, HU treatment would help to maintain a higher capacity of force production during aging in SCD.
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hal-04250804 , version 1 (02-05-2024)

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Constance Michel, David Bendahan, Benoit Giannesini, Christophe Vilmen, Yann Le Fur, et al.. Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model. Journal of Applied Physiology, 2023, 134 (2), pp.415-425. ⟨10.1152/japplphysiol.00333.2022⟩. ⟨hal-04250804⟩
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