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Communication Dans Un Congrès Année : 2018

body temperatures before and after sleep onset in preterm neonates

Résumé

Title Effects of chronic exposition to noise on homeostasis in juvenile rats Introduction One third of the developed countries population has a poor sleep quality or reduced sleep duration. One of the cause of these complains is noise. The noise is generally defined as an unwanted sound which can have auditory but also extra-auditory effects on health. Furthermore, in OECD, 100 million peoples go through noise exposure exceeding 65dB(A) whereas levels should not exceed the threshold of 55dB(A) because could provoke awakening. The aim of this study is to see the effects a chronic high level noise exposition on juvenile rats on sleep and homeostasis parameters. Materials and methods 24 3-weeks old male Wistar rats (12 control vs 12 noise exposed) were exposed or not to noise 5 weeks at 87.5 dB 50-20.000Hz, mixing environmental and artificial noises during the light-rest period of the rat (12h from 6:00 am to 6:00 pm). The noise level of control was under 65dB. After 3 weeks of exposition, rats were surged to dispose polysomnographic telemetric implants (EEGs and EMG). At 5th week of exposition, 24-hrs polysomnography was performed and total duration (min, % of Total Sleep Time, TST), frequency (ep/h), mean duration of episode (s) for Wake, NREM, REM and Quiet Wakefulness were measured. The ratios NREM/TST and REM/TST were calculated. Food and water intake and weight of the animals were recorded. At the beginning of the 6th week, plethysmography was set for 1 hour (10:00 to 11:00 in non noise-exposed area) and apneas were analyzed in correlation with sleep states. The data were analyzed with Statview software and expressed in Mean ± Standard Deviation (SD). Depending on normality (Kolmogorov-Smirnov), two-way ANOVA with PLSD Fisher post-test or Mann-Whitney analyses were performed. Differences were considered significant at p<0.05. Significant results (p<0.10) are given when consistent. Results The weight of noise group animals tended to increase compared to controls (279.5±26.7 vs 290.6±33.3 g, p=0.055). Noise exposed animals ate more (total quantity: +2.72 g/24h, p<0.001) as a result of increased number of meals (+1.2 meals/24h, p=0.001) and increased average duration of a meal (+153 s, p=0.002). Moreover, these animals drunk more (+7.3 mL/24h, p<0.001). The number of apneas significantly increased in noise exposed group (1.1±1.9 vs 3.2±5.4 apnea/h, p=0.04), whatever the sleep states. Chronic noise exposure significantly affected sleep with a diminution of Quiet Wakefulness and NREM episodes (respectively -2.3 ep/h, p=0.05 and -2.4 ep/h, p=0.003) whereas mean duration of NREM episodes increased (17.6 s; p=0.058). The other noise effects on sleep depend on nycthemeral period: during the light-rest period (noise exposure), there was no significant modification of sleep. In contrast, during the dark-activity period (no noise), total duration of NREM sleep decreased (-3.1% of TST, p=0.017) at the expense of REM sleep. Conclusions The chronic noise exposure at high-level exposure of 87.5 dB during the light-rest period induced significant sleep disturbances with modification of sleep microstructure without great modification of sleep macrostructure. These effects generally occur during the dark-rest period. Indicators of general homeostasis were also perturbed as shown by increased of body weight, hyperphagia and sleep apnea.
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Dates et versions

hal-04250181 , version 1 (19-10-2023)

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  • HAL Id : hal-04250181 , version 1

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Véronique Bach. body temperatures before and after sleep onset in preterm neonates. International pediatric sleep association congress, Apr 2018, Paris, France. ⟨hal-04250181⟩

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