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Article Dans Une Revue AJP - Heart and Circulatory Physiology Année : 2023

Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system

Arian Aghilinejad
Faisal Amlani
Sohrab Mazandarani
  • Fonction : Auteur
Kevin King
  • Fonction : Auteur

Résumé

We investigated the impact of major aging mechanisms of the arterial system and cardiac function on brain hemodynamics. Our findings suggest that aging has a significant impact on heart-aorta-brain coupling through changes in both arterial stiffening and left ventricle (LV) contractility. Understanding the underlying physical mechanisms involved here can potentially be a key step for developing more effective therapeutic strategies that can mitigate the contributions of abnormal LV-arterial coupling toward neurodegenerative diseases and dementia.
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Dates et versions

hal-04249910 , version 1 (19-10-2023)

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Arian Aghilinejad, Faisal Amlani, Sohrab Mazandarani, Kevin King, Niema Pahlevan. Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system. AJP - Heart and Circulatory Physiology, 2023, 325 (5), pp.H1193-H1209. ⟨10.1152/ajpheart.00314.2023⟩. ⟨hal-04249910⟩
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