A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue mBio Année : 2023

A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum

Résumé

M. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating persistence have been developed to characterize the physiologic and metabolic adaptations of Mtb and identify compounds active against this treatment-recalcitrant population.

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Pharmacologie

Dates et versions

hal-04248670 , version 1 (18-10-2023)

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Citer

Jansy Sarathy, Min Xie, Richard Jones, Adrienne Chang, Paulina Osiecki, et al.. A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum. mBio, 2023, 14 (2), ⟨10.1128/mbio.00598-23⟩. ⟨hal-04248670⟩

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