A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
Jansy Sarathy
(1)
,
Min Xie
(2)
,
Richard Jones
(3)
,
Adrienne Chang
(4)
,
Paulina Osiecki
(5)
,
Danielle Weiner
(6)
,
Wen-Shan Tsao
(5)
,
Maureen Dougher
(5)
,
Landry Blanc
(7)
,
Nader Fotouhi
(8)
,
Laura Via
(6)
,
Clifton Barry
(6)
,
Iwijn de Vlaminck
(4)
,
David R Sherman
(9)
,
Véronique Dartois
(5)
1
PHRI -
Public Health Research Institute [Newark]
2 CUHK - City University of Hong Kong [Hong Kong]
3 University of Kent [Canterbury]
4 Cornell University [New York]
5 Hackensack Meridian Health
6 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
7 CBMN - Chimie et Biologie des Membranes et des Nanoobjets
8 Global Alliance for TB Drug Development
9 University of Washington [Seattle]
2 CUHK - City University of Hong Kong [Hong Kong]
3 University of Kent [Canterbury]
4 Cornell University [New York]
5 Hackensack Meridian Health
6 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
7 CBMN - Chimie et Biologie des Membranes et des Nanoobjets
8 Global Alliance for TB Drug Development
9 University of Washington [Seattle]
Landry Blanc
- Fonction : Auteur
- PersonId : 754944
- IdHAL : landry-blanc
- ORCID : 0000-0001-5622-356X
- IdRef : 188820361
Véronique Dartois
- Fonction : Auteur
- PersonId : 801570
- ORCID : 0000-0001-9470-5009
Résumé
M. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating persistence have been developed to characterize the physiologic and metabolic adaptations of Mtb and identify compounds active against this treatment-recalcitrant population.