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Article Dans Une Revue Progress in Additive Manufacturing Année : 2023

Investigation and characterization of the additive manufacturing of polycaprolactone/bioactive glass hybrid scaffolds for bone tissue engineering via material extrusion processing

Résumé

Recently, additive manufacturing became the subject of intense study in biomaterials science. Thanks to their versatility and effectiveness, this family of processing techniques could completely revolutionize the field. In bone regenerative medicine, in particular, additive manufacturing seems incredibly promising in opening new avenues of development of patient-specific ad hoc therapies. They could make possible to scan a defect and precisely replicate it to offer the best fitting for each patient. The main bottleneck to date is the relatively scarce availability of materials that can be printed reliably and consistently. This is the case for organic/inorganic hybrids, materials7 produced by sol-gel chemistry that combine the advantages of polymers and bioinorganics at the molecular scale. Due to their complex structure and unique rheological and mechanical properties, the printing of hybrids remains challenging. With this study, we aim to investigate the rheological, thermal and molecular properties of a class I polycaprolactone/bioactive glass hybrid and discover how they relate to the printability of the material. The molecular weight distribution (gel permeation chromatography), thermal properties (thermal gravimetric analysis, differential scanning calorimetry) and rheological properties of each hybrid material were investigated at all stages of processing. Printing trials via direct fused deposition modeling were performed on all polymers as received and on their respective hybrids. Morphological characterization of the printed constructs was also performed. Finally, their apatite forming ability in simulated body fluid was evaluated by scanning electron microscopy and particle induced X-ray emission. Results confirmed the successful direct 3D printing of organic/inorganic hybrids for the first time. Three-dimensional scaffolds were successfully produced without the need for additional solvents or indirect approaches. Thanks to the thermal analysis, an ideal temperature window for printing was identified. SBF19 immersion assays confirmed that the material's bioactivity is retained after printing. Thanks to our findings, fused deposition modeling might develop into a suitable technique for fabricating 3D bioactive scaffolds for bone tissue engineering
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Dates et versions

hal-04248614 , version 1 (12-09-2024)

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Lukas Gritsch, Haroutioun Askanian, Vera Bednarzig, Stefan Schrüfer, Joachim Kaschta, et al.. Investigation and characterization of the additive manufacturing of polycaprolactone/bioactive glass hybrid scaffolds for bone tissue engineering via material extrusion processing. Progress in Additive Manufacturing, 2023, 9, pp.1085-1103. ⟨10.1007/s40964-023-00505-9⟩. ⟨hal-04248614⟩
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