α‐Synuclein: The Long Distance Runner
Résumé
Abstract P arkinson's disease is characterized by α‐synuclein pathology in the form of L ewy bodies and L ewy neurites. B raak et al described the spatial and temporal spread of α‐synuclein pathology in P arkinson's disease. Recent experimental studies have demonstrated that α‐synuclein can transfer from cell to cell. In this review, we highlight the involvement of α‐synuclein in P arkinson's disease and in B raak's staging of P arkinson's disease pathology. We discuss whether a prion‐like mechanism of α‐synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell‐to‐cell transfer of α‐synuclein and focus our review on the long‐distance axonal transport of α‐synuclein along neurons.