Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression.
Résumé
Premature hair greying occurs due to the depletion of melanocyte stem cells (McSCs) in the hair follicle, which can be accelerated by stress caused by genetic or environmental factors. However, the connection between stress and McSC loss is not fully understood. MiRNAs are molecules that control gene expression by regulating mRNA stability and translation, and are produced by the enzyme Dicer, which is repressed under stress. Here, using two mouse genetic models and human and mouse cell lines, we found that the inactivation of Dicer in melanocytes leads to a misplacement of these cells within the hair follicle, resulting in a lack of melanin transfer to keratinocytes in the growing hair and the exhaustion of the McSC pool. We also show that miR-92b, which regulates ItgaV mRNA and protein levels, plays a role in altering melanocyte migration. Overall, our findings suggest that the Dicer-miR92b-ItgaV pathway serves as a major signalling pathway linking stress to premature hair greying.
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Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression. - 1-s2.0-S0022202X23025903-main.pdf (7.27 Mo)
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